Mycamine Administration
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Micafungin was present in the milk of lactating rats following IV administration. Because micafungin is generally well tolerated and appears to have limited interaction with other drugs it is a potential important agent in the treatment of invasive fungal infections.
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Mycamine has been shown to precipitate when mixed directly with a number of other commonly used medications.
Mycamine administration. INDICATIONS AND USAGE ----- MYCAMINE is an echinocandin indicated in adult and pediatric patients for 1. Some experts state that if an echinocandin is used in neonates micafungin is the preferred agent. Mycamine has been shown to precipitate when mixed directly with a number of other commonly used medications.
Binding to albumin is independent of micafungin concentration 10-100 µgml. For intravenous infusion Mycamine manufacturer advises give intermittently in Glucose 5 or Sodium chloride 09. 10 MYCAMINE is a sterile lyophilized product for intravenous IV infusion that 11 contains micafungin sodium.
DOSAGE AND ADMINISTRATION Do not mix or co-infuse Mycamine with other medications. Do not use if there is any evidence of precipitation or foreign matter. INDICATIONS AND CLINICAL USE.
After reconstitution each mL contains 20 mg of micafungin. Route of Administration Dosage Form Strength Clinically Relevant Nonmedicinal Ingredients Intravenous infusion Lyophilized Powder for Injection 50 mg and 100 mg per vial Lactose citric acid andor sodium hydroxide This is a complete listing of all nonmedicinal ingredients. Monitor rate of hemolysis.
It inhibits the production of beta-13-glucan an essential component of fungal cell walls. Micafungin sodium is chemically designated as. Following intravenous administration concentrations of micafungin show a biexponential.
It explains how the Committee for Medicinal Products for Human Use CHMP assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Mycamine. Mycamine must be diluted with 09 Sodium Chloride Injection USP or 5 Dextrose Injection USP see DOSAGE AND ADMINISTRATION. The doses of Mycamine administered included doses above and below the recommended doses see Dosage and Administration 21 22 and ranged from 075 mgkg to 15 mgkg in pediatric patients and 125 mg to 150 mgday or greater in adults.
MYCAMINE is a sterile lyophilized product for intravenous IV infusion that contains micafungin sodium. Monitor hepatic function. In systemic circulation micafungin is highly bound to plasma protein 99 primarily to.
Micafungin sodium is a semisynthetic lipopeptide echinocandin synthesized by a chemical. 42 Posology and method of administration Treatment with Mycamine should be initiated by a physician experienced in the management of fungal infections. Although micafungin is approved for the treatment of invasive candidiasis dosing guidelines for micafungin in morbidly obese patients are not available.
The drug is rapidly distributed into tissues. Micafungin sold under the brand name Mycamine is a polyene antifungal medication used to treat and prevent invasive fungal infections including candidemia abscesses and esophageal candidiasis. Data are not available regarding the presence of micafungin in human milk effects on breastfed infants or effects on milk production.
Dosage and Administration Dosage for Pediatric Patients Younger than 4 Months of Age 23 122019 Warnings and Precaut ions Infusion and Injection Site Reactions 55 122019 ----- reported. Clinical Trials Experience in Adults. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
MYCAMINE 100 mg vial. Treat for at least 14 days after resolution of symptoms or last positive culture whichever is longer for candidemia without metastatic complications. Typically 85 of the steady-state concentration is achieved after three daily Mycamine doses.
When a drug is present in animal milk it is likely that the drug will be present in human milk. Micafungin sodium is a semisynthetic lipopeptide 12 echinocandin synthesized by a. Following reconstitution with 09 Sodium Chloride Injection USP the resulting pH of the solution is between 5-7.
A loading dose is not required. A loading dose is not required. Overview This is a summary of the European public assessment report EPAR for Mycamine.
Micafungin is administered intravenously. The volume of distribution at steady state Vss was approximately 18.
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